Kittitas was constructed as part of the westward expansion of the Chicago, Milwaukee, St. Paul, and Pacific Railroad, the Kittitas Yard and Depot Became the center of the community of Kittitas: one of the many small, agricultural towns that sprang up along the railroad lines. The railroad linked Kittitas to other small communities and the rest of the country, providing farmers and business people a way to sell their products in other towns and cities.

A post office, general merchandise and drug store, a Baptist Church, agricultural warehouses, and other small businesses were built around the small depot. Along with the depot, the Kittitas Yard included storage and maintenance buildings, a water tower, and other structures necessary for the maintenance of a major transcontinental railroad.

The depot is the only significant structure sill intact at the Kittitas Yard. It is an excellent example of turn-of-the-century railroad architecture, and as such was placed on the National Register of Historic Places in 1992. The depot is owned and managed by the Washington State Parks and Recreation Commission.